Lyophilization

Freeze dryers Bulova, Lyophilization

Lyophilization (or sublimation )Is a dehydration process (drying) products by quick freezing in a vacuum, where moisture evaporates, bypassing the liquid phase, and goes into a gaseous state.

Substances are freed from water (or other carrier – solvent) by turning this liquid (along with the product of course) in solid form, by freezing, and water (during lyophilization) turns into steam, when a vacuum is applied to the frozen material, these vapors are removed from the air above the frozen material, without heat.

Essentially: as you know, matter has three states: liquid, solid state, steam. (we do not take plasma into account), under the influence of heat (temperatures) these states are transformed.

Exists “Triple point” with a certain temperature and pressure, in which liquid (water or other solvent carrier) are simultaneously in three states (solid, liquid and vapor) in balance with all their physical states.

For example: water at temperature: 0,01° С and steam pressure 611,73 Pa will move to a point of equilibrium with all three physical states. AND (the principle of lyophilization) with a slight decrease in temperature and pressure (or increasing the vacuum) – water turns into steam without turning into a liquid state.

Bulova lyophilizers

Freeze-dried products are not heat-treated, which is very important for proteins and other unstable substances, for example: drugs, such, like antibodies, semi-synthetic penicillins containing immunological preparations, cephalosporins, serum.

At low temperatures, gradual, very gentle drying, the product does not lose useful properties and taste, and upon rehydration, the appearance restores its original properties!

The sublimation process begins at low temperatures from -70 ° C to -1 ° C. And the raw material is frozen to -40 ° С -70 ° С.

Lyophilization process (sublimation) flows, conditionally, in three steps:

1) Freezing, below temperature, the same triple point of matter, which you already know about. Moreover, the type of freezing is very individual for each substance. – freezing should not destroy the product cells with ice crystals.

2) Then the process takes place in a vacuum., which brings matter closer to its triple point.

Primary drying. Water (or solvent carrier) begins to evaporate and re-solidify on the cold condensation plates of the sublimator at low temperatures. At this stage, about 95% moisture. 3) Secondary drying aims to remove non-frozen water molecules. This is the process of gently heating food (triple point heating), the maximum temperature at the edges can be positive.

Sublimation allows you to preserve all the nutrients of the product, his smell, taste, and also the color, peptide bonds in cells.

Lyophilized products differ in their long shelf life – up to 25 years! Virtually any temperature condition: from -50C to + 50C.

The weight of freeze-dried products may decrease by 100 once!

Any product of animal or vegetable origin or semi-synthetic can be converted into a sublimate, be it dairy products, microorganisms (bacteria, yeast), vaccines and antitoxins, biological reagents and strains, enzymes and vitamins, proteins, fats, blood, protein organisms and substances, oils, fruit, seeds, plants and their juices.

An additional lyophilization product can be a hydrolate of the sublimated substance.

It is impossible to make a sublimate at home.. Freeze-drying or lyophilization is the industrial drying of products and substances, this requires powerful refrigeration units, and special expensive sublimation machines, in which vacuum and gentle heating of raw materials will be created.

Lyophilization is the most expensive and energy-intensive type of food drying., certainly applicable for especially valuable products and substances, unstable to heat, in which you need to save all properties and elements, and sometimes tissue structure and peptide bonds.

The price of a freeze-dried product is much higher than the price of raw materials, and the freeze drying itself takes from several hours to several days.

The term “lyophilization” – Greek origin (“dissolve (dry) with love”) not too common, more often use “Sublimation”.

Actually, the phenomenon of the transition of ice to steam was invented in 1906 year Jacques-Arcier d’Arssoval (electrophysicist) and his assistant Frédéric Bordas at the Biophysics Laboratory of the Collège de France in Paris. V 1911 Downey Harris and Shackle, employed in the Physiology Laboratory at St. Louis University, developed a freeze-drying method to preserve the rabies virus (this work eventually led to the development of the first rabies vaccine). And already in the USA it was used in the first half of the XX century in the food industry. The first food, which was prepared by sublimation method – there was freeze-dried coffee.

Freeze-drying process was developed as a commercial method, which made it possible to make the whey chemically stable and viable without the need for cooling. Shortly thereafter, cryodessication was applied to penicillin and recognized as an important technique for preserving biological substances.. Since that time, lyophilization began to be used as a method of conservation. Interesting fact: using lyophilization to restore documents, damaged by water.

Cost:

 

Equipmen Dimensions, cm

Weight

kg

Power

installed

/consumption

kW/hour

Product

 loading

mass,

L

Cost,

 

Bulova    02

45 / 51 / 80 vacuum pump separately

Package: 49 / 57 / 84 + vacuum pump separately

 

70

 

 

2,0 /1,3

 

 

2

4 000
Bulova   02 A 45 / 51 / 80 +vacuum pump separately

Remote control via APP

4 600
Bulova    12 150 / 130 / 190 +vacuum pump separately 350 7,0 / 4,5 10-12 14 000
Bulova   12 A 150 / 130 / 190 +vacuum pump separately

Remote control via APP

14 800
Bulova  100 1100 9,0 / 7,0 100 88 000
Bulova  300 4500 40,0 / 27,0 300 270 000

EU Certificate of Conformity for Mucus pro and Bulova

The cost of specialized equipment “Bulova” and “Mucus pro”, which has a Certificate of Compliance with the basic requirements of EU directives and harmonized standards of the European Union and marked with the “CE” mark increases by 20%.

HS code: 8419 39 00 90

Freeze dryer (lyophilizer) “Bulova 02”

Freeze Dryer Bulova Freeze Dryer Bulova   

Laboratory Freeze Dryer Bulova 02 designed for small laboratories and home use.

Maximum loaded product weight 2 Kg/cycle
Tray area: 1776 cm²
Tray volume: 2131 cm³ Working vacuum depth 15-180 Pa
Sublimator surface temperature, max. minus -40С°
Shelf temperature, max. + 60С°
A mass of accumulating ice 1,86 kg/cycle.
Number of shelves for raw materials – 3
Process cycle time 24-48 hours
Power consumption of all devices and units 1,3 kW/h., established: 2.0 kW/h.
Supply voltage 220-230 volt with ground
Weight no more 70 Kg
Operating temperature 10C° – 30С°
Maximum noise level 75 dB
Freon R-410a

Frame consists of several panels, from which the anterior and posterior walls are formed, cover and base. Made from thick sheet metal 0.8-1 mm and powder coated. Panels are connected to each other with screws.
Dryers Bulova 02A  is made from ASCI-304 stainless steel sheet.

drying chamber is a hollow cylinder made of ASCI-304 food grade stainless steel, equipped with a front door made of organic glass. Silicone seamless ring acts as a sealing element. The doors have a handle with a latch. Necessary branch pipes and fasteners are welded to the cylinder.

Vacuum pump It is an integral part, equipped with two 2-stage rotary vane pumps. Operates at absolute pressure 15 Pa.

Refrigeration unit consists of a low temperature compressor , evaporation part, devices that ensure their operation and regulation.

Connecting and shutoff valves – standard, used for vacuum devices.

control controller – microprocessor controlled electronic device, 7” color display and software. Allows you to maintain the desired drying parameters and drying modes, dryer control.

Shelves are a 4-tier construction of flat elements, made from food grade aluminum, to the bottom of which an electric heater is attached. On the surface of which trays with the drying product are installed. Heat from the shelves is transferred to the product by conduction and thermoradiation..

Contents of delivery:
1. Complete dryer
2. Block of shelves
3. Product trays 3-pcs.
4. Vacuum pump (pump block)
5. vacuum hose
6. User manual (the passport)
7. Package
8. Vacuum oil VM-4
Optional ASCI stainless steel product trays 430.

Transport dimensions
Number of cargo pieces: 2
1: 49/57/84 cm, 55 kg
2: 40/20/30 cm, 15 kg

 

Freeze dryer (lyophilizer) “Bulova 12”

Freeze Dryer Bulova 12 from Mucus pro Freeze Dryer Bulova 12 from Mucus proFreeze dryers buy

Freeze Dryer Bulova 12 designed for industrial use.

Maximum loaded product weight 12 Kg/cycle
tray area: 10720 cm²
Tray volume: 12860 cm³ Working vacuum depth 15-180 Pa
Sublimator surface temperature, max. minus -40С°
Shelf temperature, max. + 60С°
A mass of accumulating ice 11 kg/cycle.
Number of shelves for raw materials – 8
Process cycle time 24-48 hours
Power consumption of all devices and units 4,5 kW/h., established: 7.0 kW/h.
Supply voltage 380 volt with ground
Weight no more 350 Kg
Operating temperature 10C° – 30С°
Maximum noise level 75 dB
Freon R-410a

Frame consists of several panels, from which the anterior and posterior walls are formed, cover and base. Made from thick sheet metal 0.8-1 mm and powder coated. Panels are connected to each other with screws.
Dryers Bulova 12A is made from ASCI-304 stainless steel sheet.

drying chamber is a hollow cylinder made of ASCI-304 food grade stainless steel, equipped with a front door made of organic glass. Silicone seamless ring acts as a sealing element. The doors have a handle with a latch. Necessary branch pipes and fasteners are welded to the cylinder.

Vacuum pump It is an integral part, equipped with two 2-stage rotary vane pumps. Operates at absolute pressure 15 Pa.

Transport dimensions
Number of cargo pieces: 2
1: 150/130/170 cm, 330 kg
2: 50/40/40 cm, 20 kg

 

 

Freeze Dryer Bulova 100

Freeze-Dryer Bulova from Mucus pro for 100 kg Buy Freeze dryer for 100kg product

Freeze dryer Bulova 100 designed for industrial use.
Maximum loaded product weight 100 kg/cycle
tray area: 10 m²
Sublimator surface temperature, max. minus -40С°
Shelf temperature, max. + 60С°
A mass of storage ice 150 kg/cycle.
Number of shelves for raw materials – 10
Process cycle time 24-48 hours
Power consumption of all devices and units 14,0 kW/h., established: 19.0 kW/h.
Supply voltage 380 volt with ground
Weight no more 1350 kg
Operating temperature 10C° – 30С°
Maximum noise level 75 dB
Freon R-410a
Frame self-supporting tunnel-type freezer with two opposite doors. Monoblock construction: camera + refrigeration unit + hinged board system. All nodes and units are located in one building. Made from ASCI-304 stainless steel sheet 0.8-1 mm.

Buy a large 100 kg freeze dryer Buy Lyophilizer for 100 kg of raw materials

Drying chamber is a hollow self-supporting structure made of ASCI-304 food grade stainless steel, equipped with front doors with viewing windows made of organic glass.
Vacuum pump It is an integral part, installed 2-stage rotary vane pump. Operates at absolute pressure 15 Pa.

Transport dimensions
Number of cargo pieces: 3
1: 310/81/200 cm, 1350 kg
2: 100/50/50 cm, 80 kg
3: 120/50/120 cm, 8 kg

 

It’s very easy to start the freeze drying process!
Short video instruction on programming lyophilization recipes for Bulova freeze dryers

 

Table, for official use.
Recipes Freeze Drying.  Lyophilization modes for freeze dryers Bulova

Freeze drying recipes Freeze drying recipes

To connect the Antenna Module for monitoring and controlling Bulova D series dryers, follow the link: https://mucus.pro/modem-antenna/